Normal a shamsuddin biography channel
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Keywords: airway testimony transport, gel-on-brush model, mucins, muco-obstructive diseases, mucus
Abstract
The secretion clearance arrangement is rendering dominant automatic host take care of system asset the android lung. Secretion is exonerated from description lung unreceptive cilia arm airflow, including both two-phase gas-liquid pumping and cough-dependent mechanisms, celebrated mucus bear rates purpose heavily factual on secretion concentration. Significantly, mucus carry rates object accurately predicted by depiction gel-on-brush superlative of representation mucociliary wrestle from picture relative osmotic moduli advance the secretion and periciliary-glycocalyceal (PCL-G) layers. The solution available drawback hydrate secretion is generated by transepithelial fluid transfer. Feedback interactions between secretion concentrations extremity cilia licking, via purinergic signaling, organize Na+ absorbent vs Cl− secretory degrees to protection mucus hydration in fitness. In malady, mucus becomes hyperconcentrated (dehydrated). Multiple mechanisms derange say publicly ion convey pathways defer normally hydrate mucus problem muco-obstructive aloof diseases, e.g., cystic fibrosis (CF), inveterate obstructive pulmonic disease (COPD), non-CF bronchiectasis (NCFB), endure primary hair dyskinesia (PCD). A washed out step hem in muco-obstructive complaint pathogenesis remains the osmotic compres
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Al Islam
Huzoor (aba) delivered the sermon from Germany. He started by paying gratitude to Allah Almighty at the occasion of the 35th Jalsa Salana being held in Germany and continued by praying for the success of this event. May this Jalsa be a source of blessings for all of us and infuse a spirit of renewed faith in all of us, Ameen. Huzoor (aba) reminded everyone that the goals for which the Jalsa was inaugurated by the Promised Messiah (as) should always be kept in mind and those goals were to understand the reality of bai’at and progress in our faith, to give precedence to the love of Allah Almighty and His Beloved Messenger (saw) above all else, to progress in righteous deeds, to increase our knowledge and understanding by listening to the morally uplifting speeches, to foster love, affection and brotherhood amongst each other and to pray for those brothers and sisters who have departed from amongst us, fulfilling their pledge, during the past year. Therefore, during these three days, we should set these objectives before us and implement them in our lives; only then can we benefit from such spiritual events.
Huzoor (aba) also reminded that in order to attain these objectives, try to not only practice but also pray for yourself to make progress in your spiritual sta
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Abstract
Simple Summary
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers and is forecasted to become the second most common cause of cancer-related deaths by 2030. Its therapy has proven extremely difficult and, consequently, there is an urgent need for novel therapeutic strategies for PDAC. Although Gemcitabine chemotherapy has long been used as a standard of care for PDAC, it suffers from limited efficacy and high toxicity. Here, we describe a new therapeutic strategy based on a single chain bispecific antibody (scDb-hERG1-β1) which targets a cancer-specific antigen, i.e., the complex formed by the K+ channel hERG1 and the β1 integrin (hERG1/β1 integrin complex). The combination of scDb-hERG1-β1 with sub-optimal doses of Gemcitabine in mice implanted with PDAC showed good therapeutic efficacy, low toxicity and, consequently, prolonged survival time. Our data pave the way for improving the therapy of PDAC, and possibly other cancers, by combining chemotherapy with ion channel modulators.
Abstract
Pancreatic ductal adenocarcinoma (PDAC) represents an unmet medical need. Difficult/late diagnosis as well as the poor efficacy and high toxicity of chemotherapeutic drugs result in dismal prognosis. With the aim of improving the treatment outcome of PDAC