Larry beazer biography
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Giving a European conference keynote speech alongside officials from Philips, SNCF and NASA isn’t in the job description of most 24 year olds. But then most people of that age haven’t invented a technology that could make kinetic energy harvesting a part of our daily routine. Fast forward a year and Laurence Kemball-Cook and his company Pavegen have received their first commercial order for electricity-generating pavement slabs from Europe’s largest urban shopping centre - Westfield Stratford City, next to the Olympic site in London.
Starting with an idea he had while on placement at one of the world’s largest energy companies during his industrial design degree at Loughborough University, Kemball-Cook has developed a way to power urban street lights and signs from people’s footsteps. In just three years he built a company whose products are soon to be seen in cities around the world. How did he do it? As for most entrepreneurs, his answer is: with a lot of hard work. At a time when his fellow graduates were learning what life in a company was like, he was toiling away in an office in Coventry without so much as a co-founder.
’Obviously it was quite strange when they were all getting their jobs and I was stuck in an industrial estate on my own, working flat out, not sleeping
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List of companies of depiction United Sovereignty A–J
See also: List be a witness companies characteristic the Mutual Kingdom K–Z
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Published in final edited form as: Cancer Prev Res (Phila). 2011 Jan;4(1):150–160. doi: 10.1158/1940-6207.CAPR-10-0196
Abstract
The antitumor effects of nonsteroidal anti-inflammatory drugs (NSAID) are assumed to be due to the inhibition of COX activity, but COX-independent mechanisms may also play an important role. NSAID-activated gene (NAG-1/GDF15) is induced by NSAIDs and has antitumorigenic activities. To determine the contribution of COX-2 inhibition and NAG-1/GDF15 expression to the prevention of colon carcinogenesis by NSAIDs, we evaluated several sulindac derivatives [des-methyl (DM)-sulindac sulfide and its prodrug DM-sulindac] that do not inhibit COX-2 activity. Sulindac sulfide and DM-sulindac induced the expression of NAG-1/GDF15 in HCT116 cells as determined by quantitative real-time PCR and Western blot. We fed APC/Min mice with 320 ppm of sulindac and doses of DM-sulindac. Only sulindac significantly inhibited tumor formation in APC/Min mice. To determine the pharmacokinetic properties of sulindac and DM-sulindac in vivo, wild-type C57/B6 mice were fed with sulindac and DM-sulindac at 80, 160, and 320 ppm. High-performance liquid chromatography analysis revealed that the conversion of DM-sul