David seyfert ruegg biography examples
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Published in final edited form as: Dev Cell. 2021 Oct 4;56(19):2722–2740.e6. doi: 10.1016/j.devcel.2021.09.008
Summary
Spiny mice (Acomys cahirinus) are terrestrial mammals that evolved unique scar-free regenerative wound healing properties. Myofibroblasts (MFs) are the major scar-forming cell type in skin. We found that following traumatic injury to ear pinnae, MFs appeared rapidly in both Acomys and mouse yet persisted only in mouse. The timing of MF loss in Acomys correlated with wound closure, blastema differentiation, and nuclear localization of the Hippo pathway target protein Yap. Experiments in vitro revealed an accelerated PP2A-dependent dephosphorylation activity that maintained nuclear Yap in Acomys dermal fibroblasts (DFs) and was not detected in mouse or human DFs. Treatment of Acomys in vivo with the nuclear Yap-TEAD inhibitor verteporfin prolonged MF persistence and converted tissue regeneration to fibrosis. Forced Yap activity prevented and rescued TGFβ1-induced human MF formation in vitro. These results suggest Acomys evolved modifications of Yap activity and MF fate important for scar-free regenerative wound healing in vivo.
Keywords: regeneration, fibrosis, myofibroblast, Hippo-Yap
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Roger Stupp, MD
Professor, Neurological Surgery; Feinberg School of Medicine
Research Program
- Translational Research in Malignancy (TRIM)
roger.stupp( at )northwestern.edu
Cancer-Focused Research
After completion of my clinical training in oncology/hematology,I have devoted my career to innovative treatments of cancer, with a special focus on brain tumors. While single modality treatment approaches may not suffice to demonstrate meaningful improvement in outcome in heterogeneous and molecularly complex solid tumors, my focus has been on combination treatments and association of various treatment modalities.Understanding of pathogenesis and biology will enable substantial treatment advances, thus my dedication has been on translation not only form the lab to the bedside, but also from the clinic back to the bench. Jointly with my colleagues in basic, translational, and clinical research I have been involved with the development of several novel treatments for glioblastoma. Most notably, our close interdisciplinary interaction allowed for establishing two new FDA-approved treatments for glioblastoma that remain the worldwide standard of care. From 2012 until 2017, I have served as the president of the European Organisation for Research and Treatment of Ca
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Abstract
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